Sentinel Innovation Center (IC)

Sentinel Innovation Center (IC)

The Sentinel Innovation Center is a test bed to identify, develop, and evaluate innovative methods to study drug safety and effectiveness using real-world data. The IC was created in response to FDA’s Medical Data Enterprise Initiative to build a new system containing electronic health records from 10 million lives and the Sentinel Five-Year Strategy. Achieving this vision requires:

  • Developing new analysis tools for unstructured EHR data
  • Establishing novel data sources by finding new ways to extract, standardize and quality check clinical data and free-text in EHRs
  • Creating state-of-the-art approaches to identify clinical phenotypes, extract key data elements and adjust for confounding in drug safety and effectiveness studies


Lesley Curtis portrait photo
Lesley Curtis, PhD
IC Executive Leadership
Rishi Desai portrait photo
Rishi J Desai, PhD
IC Operations Chief
Patrick Heagerty portrait photo
Patrick Heagerty, PhD
IC Executive Leadership
Kevin Johnson portrait photo
Kevin Johnson, MD, MS
IC Executive Leadership
Keith Marsolo portrait photo
Keith Marsolo, PhD
IC Executive Leadership
Michael Matheny portrait photo
Michael E. Matheny, MD, MS, MPH
IC Executive Leadership
Jennifer Nelson portrait photo
Jennifer Clark Nelson, PhD
IC Executive Leadership
Sebastian Schneeweiss portrait photo
Sebastian Schneeweiss, MD, ScD
IC Executive Director
Shirley Wang portrait photo
Shirley Wang, PhD, ScM
IC Lead Epidemiologist

Lead Hubs

The IC has four Lead Hubs. These four hubs make up the Executive Leadership Team. Below are the four Lead Hubs in the Executive Leadership Team.

  1. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School
  2. Duke Clinical Research Institute
  3. Vanderbilt University Medical Center Department of Biomedical Informatics
  4. Kaiser Permanente Washington Health Research Institute & University of Washington School of Public Health

Advisory Board

The Advisory Committee supports the Lead Hubs. The Advisory Committee provides strategic guidance to the IC. It comprises top thought leaders in healthcare innovation. This includes academia, government, and industry. 

Innovation Cores

The Innovation Cores identify novel technologies that could lead to new innovation projects. 

Innovation Partners and the National Network of Innovation Experts

Innovation Partners are industry leaders in technology innovation. 

The National Network of Innovation Experts also works with the Innovation Cores. It comprises individuals in academic and other research settings.  They have expertise in various domains of methods, innovation, and technology. 

Together, these two groups lead and support projects within the IC. They are innovators and pioneers in: 

  • data science
  • pharmacoepidemiology
  • biostatistics
  • biomedical informatics
  • natural language processing
  • machine learning and other areas of artificial intelligence
  • signal detection
  • advanced causal inference methods
  • data linkage and integration
  • pragmatic trials
  • real-world evidence generation

Below is a list of Advisory Committee members, Innovation Partners, and National Network of Innovation Experts.

  • Aetion
  • Amazon
  • American Medical Informatics Association
  • Boston Children’s Hospital
  • Columbia University
  • Concerto HealthAI
  • Corrona
  • Duke Margolis Center for Health Policy
  • Duke University
  • Epic
  • Evidation
  • General Dynamics Information Technology (GDIT)
  • Harvard School of Public Health
  • HCA Healthcare
  • Healthagen (Aetna)
  • HealthCore
  • HealthPartners Institute
  • Health Sciences South Carolina
  • Humana
  • Kaiser Permanente Colorado Institute for Health Research
  • Kaiser Permanente Hawaii
  • Kaiser Permanente Mid-Atlantic
  • Kaiser Permanente Northern California
  • Kaiser Permanente Northwest
  • Marshfield Clinic
  • Massachusetts General Hospital
  • MDxHealth
  • Medical University of South Carolina
  • Microsoft Healthcare NExT
  • Microsoft Research
  • Northeastern University
  • Oak Ridge National Laboratory
  • Observational Health Data Sciences and Informatics (OHDSI)
  • Optum Labs
  • Optum Life Sciences
  • Partners HealthCare System
  • PatientsLikeMe
  • Penn State University
  • Putnam Data Sciences
  • PRACnet (Humana)
  • Rutgers University
  • Stanford University
  • STAR Clinical Research Network
  • TriNetX
  • University of Alabama
  • University of California, Berkeley
  • University of Illinois
  • University of Iowa
  • University of Florida
  • University of Michigan
  • University of Pennsylvania
  • University of Pittsburgh School of Medicine
  • University of Tennessee
  • University of Utah
  • Veradigm

The Innovation Center was created to attract new data partnerships, engage external investigators to develop new methods, and grow the types of questions that can be addressed in the Sentinel System.

The IC has developed a scientific blueprint for the next five years, named the IC Master Plan. The Master Plan has four key strategic priority areas:

  • Data infrastructure
  • Feature engineering
  • Causal inference
  • Detection analytics

The first two priority areas help to establish a query-ready distributed data network containing electronic health records. The second two priorities help develop and evaluate new methods that can be transformed into reusable analytic tools.