Sentinel as a National Resource

The Sentinel System's tools and common data model have been leveraged by many investigators, including those from academia, industry, other research networks, and other federal agencies. Sentinel’s publicly available resources have helped these researchers conduct a wide variety of studies, showing how Sentinel has accelerated important scientific work beyond drug safety. Below, we list publications that describe how Sentinel has contributed to advancing science and public health. We encourage authors who have leveraged Sentinel’s tools and common data model to contact us to add their publications below.

Use of Sentinel Tools and Data Model by Other Systems

Biologics and Biosimilars Collective Intelligence Consortium (BBCIC)

Learn more about BBCIC


BBCIC Research Network Analysis of First-Cycle Prophylactic G-CSF Use in Patients Treated with High Neutropenia Risk Chemotherapy

Pamala A. Pawloski, Cara L. McDermott, James H. Marshall, Vanita Pindolia, Catherine M. Lockhart, Catherine A. Panozzo, Jeffrey S. Brown, and Bernadette Eichelberger
August 16, 2021
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Patient Characteristics and Utilization Patterns of Short-Acting Recombinant Granulocyte Colony-Stimulating Factor (G-CSF) Biosimilars Compared to Their Reference Product

Aaron B. Mendelsohn, James Marshall, Cara L McDermott, Pamala A. Pawloski, Jeffrey S. Brown, Catherine M. Lockhart
January 30, 2021
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Utilization Patterns and Characteristics of Users of Biologic Anti-Inflammatory Agents in a Large, US Commercially Insured Population

Aaron B. Mendelsohn, Young Hee Nam, James Marshall, Cara L. McDermott, Bharati Kochar, Michael D. Kappelman, Jeffrey S. Brown, Catherine M. Lockhart
December 29, 2020
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Incidence of Serious Infections and Design of Utilization and Safety Studies for Biologic and Biosimilar Surveillance

Jie Zhang, Gayathri Sridhar, Charles E. Barr, Bernadette Eichelberger, Catherine M. Lockhart, James Marshall, Jerry Clewell, Neil A. Accortt, Jeffrey R. Curtis, Cynthia Holmes, Cheryl N. McMahill-Walraven, Jeffrey S. Brown, Kevin Haynes
April 26, 2020
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Mapping from the International Classification of Diseases (ICD) 9th to 10th Revision for Research in Biologics and Biosimilars Using Administrative Healthcare Data

Mengdong He, Adrian J. Santiago Ortiz, James Marshall, Aaron B. Mendelsohn, Jeffrey R. Curtis, Charles E. Barr, Catherine M. Lockhart, Seoyoung C. Kim
December 18, 2019
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Capture of Biologic and Biosimilar Dispensings in a Consortium of U.S.‐Based Claims Databases: Utilization of National Drug Codes and Healthcare Common Procedure Coding System Modifiers in Medical Claims

Jie Zhang, Kevin Haynes, Aaron B. Mendelsohn, James Marshall, Charles E. Barr, Cara McDermott, Jeffrey Brown, Annemarie Kline, James Kenney, Katelyn J. King, Cynthia Holmes, Kai Yeung, John Barron, Huifeng Yun, Catherine M. Lockhart
December 4, 2019
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Descriptive Analysis of Long- and Intermediate-Acting Insulin and Key Safety Outcomes in Adults with Type 2 Diabetes Mellitus

Daniel J. Kent, Cheryl McMahill-Walraven, Catherine Panozzo, Pamala A. Pawloski, Kevin Haynes, James Marshall, Jeffrey S. Brown, Bernadette Eichelberger, Catherine M. Lockhart
August 16, 2019
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Barriers and Facilitators to Conduct High‐Quality, Large‐Scale Safety and Comparative Effectiveness Research: The Biologics and Biosimilars Collective Intelligence Consortium Experience

Catherine M. Lockhart, Cara L. McDermott, Thomas Felix, Nancy D. Lin, Mark J. Cziraky, Aaron B. Mendelsohn, Jeffrey S. Brown
August 11, 2019
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Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to Evaluate Patterns of Care

Cheryl N. McMahill-Walraven, Daniel J. Kent, Catherine A. Panozzo, Pamala A. Pawloski, Kevin Haynes, James Marshall, Jeffrey S. Brown, Bernadette Eichelberger, Catherine M. Lockhart
August 9, 2019
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Learn more about the NIH Collaboratory DRN


Identifying Prescribing Cascades in Alzheimer's Disease and Related Dementias: The Calcium Channel Blocker-Diuretic Prescribing Cascade

Sonal Singh, Noelle M. Cocoros, Kevin Haynes, Vinit P. Nair, Thomas P. Harkins, Paula A. Rochon, Richard Platt, Inna Dashevsky, Juliane Reynolds, Kathleen M. Mazor, Sarah Bloomstone, Kathryn Anzuoni, Sybil L. Crawford, Jerry H Gurwitz
March 14, 2021
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Diagnosed Prevalence of Alzheimer's Disease and Related Dementias in Medicare Advantage Plans

Eric Jutkowitz, Julie P.W. Bynum, Susan L. Mitchell, Noelle M. Cocoros, Oren Shapira, Kevin Haynes, Vinit P. Nair, Cheryl N. McMahill‐Walraven, Richard Platt, Ellen P. McCarthy
July 5, 2020
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Considerations for Using Distributed Research Networks to Conduct Aspects of Randomized Trials

Keith A. Marsolo, Jeffrey S. Brown, Adrian F. Hernandez, Bradley G. Hammill, Sudha R. Raman, Beth Syat, Richard Platt, Lesley H Curtis
January 2, 2020
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Incidence of Statin Use in Older Adults with and without Cardiovascular Disease and Diabetes Mellitus, January 2008 - March 2018

Catherine A. Panozzo, Lesley Curtis, James Marshall, Lawrence Fine, Barbara L. Wells, Jeffrey S. Brown, Kevin Haynes, Pamala A. Pawloski, Adrian F. Hernandez, Sarah Malek, Beth Syat, Richard Platt
December 5, 2019
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Chemotherapy-Induced Peripheral Neuropathy (CIPN) and its Treatment: An NIH Collaboratory Study of Claims Data

Jennifer Gewandter, Amber Kleckner, James Marshall, Jeffery S. Brown, Lesley Curtis, Javier Bautista, Robert Dworkin, Ian Kleckner, Noah Kolb, Supriya Mohile, Karen Mustian
September 7, 2019
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Antibiotic Dispensing Following Pediatric Visits in the US Emergency Departments and Outpatient Settings from 2006 to 2016

Abiy Agiro, Gayathri Sridhar, Aliza Gordon, Jeffrey S. Brown, Kevin Haynes
August 27, 2019
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Cancer Screening Results and Follow-up Using Routinely Collected Electronic Health Data: Estimates for Breast, Colon, and Cervical Cancer Screenings

Sudha Raman, Jeffrey S. Brown, Lesley Curtis, Kevin Haynes, James Marshall, Pamala Pawloski, Richard Platt
March 15, 2019
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Learn more about the Reagan-Udall Foundation and IMEDS


Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients Treated with Biologic and Non-Biologic DMARDs

Judith C. Maro, Talia Menzin, Kenneth Hornbuckle, Jon T. Giles, Arthur Kavanaugh, Thomas Dörner, David Martin, Ting-Ying Huang, Claudia A. Salinas
June 16, 2018
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Do FDA Label Changes Work? Assessment of the 2010 Class Label Change for Proton Pump Inhibitors Using the Sentinel System's Analytic Tools

Rachel E. Sobel, Andrew Bate, James Marshall, Kevin Haynes, Nandini Selvam, Vinit Nair, Gregory Daniel, Jeffrey S. Brown, Robert F. Reynolds
March 27, 2018
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Health Outcomes Coding Trends in the US Food and Drug Administration's Sentinel System during Transition to International Classification of Diseases-10 Coding System: A Brief Review

Young Hee Nam, Aaron B. Mendelsohn, Catherine A. Panozzo, Judith C. Maro, Jeffrey S. Brown
February 27, 2021
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Building an Active Medical Product Safety Surveillance System in Taiwan: Adaptation of the U.S. Sentinel System Common Data Model Structure to the National Health Insurance Research Database in Taiwan   

Kelly Huang, Fang‐Ju Lin, Huang‐Tz Ou, Chien‐Ning Hsu, Ling‐Ya Huang, Chi‐Chuan Wang, Sengwee Toh
November 4, 2020
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Impact of the Transition from ICD–9–CM to ICD–10–CM on the Identification of Pregnancy Episodes in US Health Insurance Claims Data

Amir Sarayani, Xi Wang, Thuy Nhu Thai, Yasser Albogami, Nakyung Jeon, Almut G. Winterstein
October 15, 2020
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Safety Surveillance and the Estimation of Risk in Select Populations: Flexible Methods to Control for Confounding while Targeting Marginal Comparisons via Standardization

Xu Shi, Robert Wellman, Patrick J. Heagerty, Jennifer C. Nelson, Andrea J. Cook
December 10, 2019
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Replication of Mini-Sentinel Study Assessing Mirabegron and Cardiovascular Risk in Non-Mini-Sentinel Databases

Jason Simeone, Beth Nordstrom, Kwame Appenteng, Samuel Huse, Milbhor D’Silva
March 5, 2018
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A Comparative Assessment of Observational Medical Outcomes Partnership and Mini-Sentinel Common Data Models and Analytics: Implications for Active Drug Safety Surveillance

Yihua Xu, Xiaofeng Zhou, Brandon Suehs, Abraham Hartzema, Michael Kahn, Yola Moride, Brian Sauer, Qing Liu, Keran Moll, Margaret Pasquale, Vinit Nair, Andrew Bate
June 9, 2015
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Use of Sentinel Tools and Data Model by Other Agencies

Incidence of Latent Tuberculosis Infection: A Descriptive Analysis

In this report we describe baseline and post-index characteristics of patients diagnosed and treated for latent tuberculosis infection (LTBI) or tuberculosis (TB), estimated time from LTBI or TB diagnosis to treatment, time from LTBI or TB test to treatment, and time from LTBI diagnosis to TB diagnosis in the Sentinel Distributed Database. The study period spanned from January 1, 2008 to December 31, 2019. We distributed this request to 16 Data Partners on June 30, 2020.
View the report