Sentinel as a National Resource

Many investigators, including those from academia, industry, other research networks, and other federal agencies, have leveraged the Sentinel System’s infrastructure including tools and common data model. These resources have helped researchers conduct a wide variety of studies, showing how Sentinel has accelerated important scientific work beyond drug safety. The following content illustrates how Sentinel has contributed to advancing science and public health. We encourage authors to contact us to add their work products below.


Organizations that have used Sentinel’s tools include the following, in addition to others:

Search Sentinel as a National Resource

Title Type Author(s) Date Posted Entity
BBCIC Research Network Analysis of First-Cycle Prophylactic G-CSF Use in Patients Treated with High Neutropenia Risk Chemotherapy
Publication

Publication
Pamala A. Pawloski, Cara L. McDermott, James H. Marshall, Vanita Pindolia, Catherine M. Lockhart, Catherine A. Panozzo, Jeffrey S. Brown, and Bernadette Eichelberger
08/16/2021 BBCIC
Identifying Prescribing Cascades in Alzheimer's Disease and Related Dementias: The Calcium Channel Blocker-Diuretic Prescribing Cascade
Publication

Publication
Sonal Singh, Noelle M. Cocoros, Kevin Haynes, Vinit P. Nair, Thomas P. Harkins, Paula A. Rochon, Richard Platt, Inna Dashevsky, Juliane Reynolds, Kathleen M. Mazor, Sarah Bloomstone, Kathryn Anzuoni, Sybil L. Crawford, Jerry H. Gurwitz
03/14/2021 NIH
Health Outcomes Coding Trends in the US Food and Drug Administration's Sentinel System During Transition to International Classification of Diseases-10 Coding System: A Brief Review
Publication

Publication
Young Hee Nam, Aaron B. Mendelsohn, Catherine A. Panozzo, Judith C. Maro, Jeffrey S. Brown
02/27/2021 Other Organization
Incidence of Latent Tuberculosis Infection: A Descriptive Analysis
Sentinel Analysis

Sentinel Analysis
02/12/2021 CDC
Patient Characteristics and Utilization Patterns of Short-Acting Recombinant Granulocyte Colony-Stimulating Factor (G-CSF) Biosimilars Compared to Their Reference Product
Publication

Publication
Aaron B. Mendelsohn, James Marshall, Cara L McDermott, Pamala A. Pawloski, Jeffrey S. Brown, Catherine M. Lockhart
01/30/2021 BBCIC
Utilization Patterns and Characteristics of Users of Biologic Anti-Inflammatory Agents in a Large, US Commercially Insured Population
Publication

Publication
Aaron B. Mendelsohn, Young Hee Nam, James Marshall, Cara L. McDermott, Bharati Kochar, Michael D. Kappelman, Jeffrey S. Brown, Catherine M. Lockhart
12/29/2020 BBCIC
Building an Active Medical Product Safety Surveillance System in Taiwan: Adaptation of the U.S. Sentinel System Common Data Model Structure to the National Health Insurance Research Database in Taiwan
Publication

Publication
Kelly Huang, Fang‐Ju Lin, Huang‐Tz Ou, Chien‐Ning Hsu, Ling‐Ya Huang, Chi‐Chuan Wang, Sengwee Toh
11/04/2020 Other Organization
Impact of the Transition from ICD–9–CM to ICD–10–CM on the Identification of Pregnancy Episodes in US Health Insurance Claims Data
Publication

Publication
Amir Sarayani, Xi Wang, Thuy Nhu Thai, Yasser Albogami, Nakyung Jeon, Almut G. Winterstein
10/15/2020 Other Organization
Diagnosed Prevalence of Alzheimer's Disease and Related Dementias in Medicare Advantage Plans
Publication

Publication
Eric Jutkowitz, Julie P. W. Bynum, Susan L. Mitchell, Noelle M. Cocoros, Oren Shapira, Kevin Haynes, Vinit P. Nair, Cheryl N. McMahill‐Walraven, Richard Platt, Ellen P. McCarthy
07/05/2020 NIH
Incidence of Serious Infections and Design of Utilization and Safety Studies for Biologic and Biosimilar Surveillance
Publication

Publication
Jie Zhang, Gayathri Sridhar, Charles E. Barr, Bernadette Eichelberger, Catherine M. Lockhart, James Marshall, Jerry Clewell, Neil A. Accortt, Jeffrey R. Curtis, Cynthia Holmes, Cheryl N. McMahill-Walraven, Jeffrey S. Brown, Kevin Haynes
04/26/2020 BBCIC
Considerations for Using Distributed Research Networks to Conduct Aspects of Randomized Trials
Publication

Publication
Keith A. Marsolo, Jeffrey S. Brown, Adrian F. Hernandez, Bradley G. Hammill, Sudha R. Raman, Beth Syat, Richard Platt, Lesley H. Curtis
01/02/2020 NIH
Mapping from the International Classification of Diseases (ICD) 9th to 10th Revision for Research in Biologics and Biosimilars Using Administrative Healthcare Data
Publication

Publication
Mengdong He, Adrian J. Santiago Ortiz, James Marshall, Aaron B. Mendelsohn, Jeffrey R. Curtis, Charles E. Barr, Catherine M. Lockhart, Seoyoung C. Kim
12/18/2019 BBCIC
Safety Surveillance and the Estimation of Risk in Select Populations: Flexible Methods to Control for Confounding while Targeting Marginal Comparisons via Standardization
Publication

Publication
Xu Shi, Robert Wellman, Patrick J. Heagerty, Jennifer C. Nelson, Andrea J. Cook
12/10/2019 Other Organization
Incidence of Statin Use in Older Adults With and Without Cardiovascular Disease and Diabetes Mellitus, January 2008 - March 2018
Publication

Publication
Catherine A. Panozzo, Lesley H. Curtis, James Marshall, Lawrence Fine, Barbara L. Wells, Jeffrey S. Brown, Kevin Haynes, Pamala A. Pawloski, Adrian F. Hernandez, Sarah Malek, Beth Syat, Richard Platt
12/05/2019 NIH
Capture of Biologic and Biosimilar Dispensings in a Consortium of U.S.‐Based Claims Databases: Utilization of National Drug Codes and Healthcare Common Procedure Coding System Modifiers in Medical Claims
Publication

Publication
Jie Zhang, Kevin Haynes, Aaron B. Mendelsohn, James Marshall, Charles E. Barr, Cara McDermott, Jeffrey Brown, Annemarie Kline, James Kenney, Katelyn J. King, Cynthia Holmes, Kai Yeung, John Barron, Huifeng Yun, Catherine M. Lockhart
12/04/2019 BBCIC
Chemotherapy-Induced Peripheral Neuropathy (CIPN) and its Treatment: An NIH Collaboratory Study of Claims Data
Publication

Publication
Jennifer Gewandter, Amber Kleckner, James Marshall, Jeffrey S. Brown, Lesley Curtis, Javier Bautista, Robert Dworkin, Ian Kleckner, Noah Kolb, Supriya Mohile, Karen Mustian
09/07/2019 NIH
Antibiotic Dispensing Following Pediatric Visits in the US Emergency Departments and Outpatient Settings from 2006 to 2016
Publication

Publication
Abiy Agiro, Gayathri Sridhar, Aliza Gordon, Jeffrey S. Brown, Kevin Haynes
08/27/2019 NIH
Descriptive Analysis of Long- And Intermediate-Acting Insulin and Key Safety Outcomes in Adults With Type 2 Diabetes Mellitus
Publication

Publication
Daniel J. Kent, Cheryl N. McMahill-Walraven, Catherine A. Panozzo, Pamala A. Pawloski, Kevin Haynes, James Marshall, Jeffrey Brown, Bernadette Eichelberger, Catherine M. Lockhart
08/12/2019 BBCIC
Barriers and Facilitators to Conduct High‐Quality, Large‐Scale Safety and Comparative Effectiveness Research: The Biologics and Biosimilars Collective Intelligence Consortium Experience
Publication

Publication
Catherine M. Lockhart, Cara L. McDermott, Thomas Felix, Nancy D. Lin, Mark J. Cziraky, Aaron B. Mendelsohn, Jeffrey S. Brown
08/11/2019 BBCIC
Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to Evaluate Patterns of Care
Publication

Publication
Cheryl N. McMahill-Walraven, Daniel J. Kent, Catherine A. Panozzo, Pamala A. Pawloski, Kevin Haynes, James Marshall, Jeffrey Brown, Bernadette Eichelberger, Catherine M. Lockhart
08/09/2019 BBCIC
Cancer Screening Results and Follow-up Using Routinely Collected Electronic Health Data: Estimates for Breast, Colon, and Cervical Cancer Screenings
Publication

Publication
Sudha Raman, Jeffrey S. Brown, Lesley Curtis, Kevin Haynes, James Marshall, Pamala Pawloski, Richard Platt
10/22/2018 NIH
Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients Treated with Biologic and Non-Biologic DMARDs
Publication

Publication
Judith C. Maro, Talia Menzin, Kenneth Hornbuckle, Jon T. Giles, Arthur Kavanaugh, Thomas Dörner, David Martin, Ting-Ying Huang, Claudia A. Salinas
06/16/2018 Reagan-Udall Foundation
Do FDA Label Changes Work? Assessment of the 2010 Class Label Change for Proton Pump Inhibitors Using the Sentinel System's Analytic Tools
Publication

Publication
Rachel E. Sobel, Andrew Bate, James Marshall, Kevin Haynes, Nandini Selvam, Vinit Nair, Gregory Daniel, Jeffrey S. Brown, Robert F. Reynolds
03/27/2018 Reagan-Udall Foundation
Replication of Mini-Sentinel Study Assessing Mirabegron and Cardiovascular Risk in Non-Mini-Sentinel Databases
Publication

Publication
Jason Simeone, Beth Nordstrom, Kwame Appenteng, Samuel Huse, Milbhor D’Silva
03/05/2018 Other Organization
A Comparative Assessment of Observational Medical Outcomes Partnership and Mini-Sentinel Common Data Models and Analytics: Implications for Active Drug Safety Surveillance
Publication

Publication
Yihua Xu, Xiaofeng Zhou, Brandon Suehs, Abraham Hartzema, Michael Kahn, Yola Moride, Brian Sauer, Qing Liu, Keran Moll, Margaret Pasquale, Vinit Nair, Andrew Bate
06/09/2015 Other Organization