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Validation of Severe Liver Injury Cases

    Basic Details
    Date Posted
    Status
    Complete
    Health Outcome(s)
    severe liver injury
    Study Type
    Validations Supported by Traditional Medical Chart Review
    Description

    Project to assess the positive predictive value of a diagnosis and procedure code-based algorithm for identifying cases of severe liver injury in electronic healthcare databases using an expert panel to review extracts from full-text medical records stripped of direct identifiers.

    Additional Information
    Data Source(s)
    Mini-Sentinel Distributed Database (MSDD)
    Workgroup Leader(s)

    Vincent Lo Re, MD, MSCE; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA

    Workgroup Member(s)

    Gregory W. Daniel, PhD, MPH, RPh; HealthCore, Inc., Wilmington, DE

    Pamala A. Pawloski, PharmD; HealthPartners Research Foundation, Bloomington, MN

    T. Craig Cheetham, PharmD, MS; Pharmacy Analytical Service, Kaiser Permanente Southern California, Downey, CA

    Kevin Haynes, PharmD, MSCE; Kimberly Fortier, MPH; David Goldberg, MD, MSCE; Sean Hennessy, PharmD, PhD; K. Rajender Reddy, MD; and Kimberly A. Forde, MD, MHS; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA