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Validation of Severe Liver Injury Cases

Basic Details
Date Posted
Status
Complete
Health Outcome(s)
severe liver injury
Study Type
Validations Supported by Traditional Medical Chart Review
Description

Project to assess the positive predictive value of a diagnosis and procedure code-based algorithm for identifying cases of severe liver injury in electronic healthcare databases using an expert panel to review extracts from full-text medical records stripped of direct identifiers.

Deliverable(s) (1)
Health Outcome of Interest Validations and Literature Reviews Validation of Severe Liver Injury Cases
Additional Information
Data Source(s)
Mini-Sentinel Distributed Database (MSDD)
Related Link(s)
Validity of diagnostic codes to identify cases of severe acute liver injury in the U.S. FDA's MSDD
Workgroup Leader(s)

Vincent Lo Re, MD, MSCE; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA

Workgroup Member(s)

Gregory W. Daniel, PhD, MPH, RPh; HealthCore, Inc., Wilmington, DE

Pamala A. Pawloski, PharmD; HealthPartners Research Foundation, Bloomington, MN

T. Craig Cheetham, PharmD, MS; Pharmacy Analytical Service, Kaiser Permanente Southern California, Downey, CA

Kevin Haynes, PharmD, MSCE; Kimberly Fortier, MPH; David Goldberg, MD, MSCE; Sean Hennessy, PharmD, PhD; K. Rajender Reddy, MD; and Kimberly A. Forde, MD, MHS; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA