Approaches to Handling Partially Observed Confounder Data From Electronic Health Records (EHR) In Non-randomized Studies of Medication Outcomes

Janick Weberpals, PhD; Robert Glynn, PhD, ScD; Luke Zabotka, BA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

Sudha Raman, PhD; Brad Hammill, PhD; Department of Population Health Sciences, Duke University of School of Medicine, Raleigh, NC

Elizabeth Messenger-Jones, MSPH; Darren Toh, ScD; John Connolly, ScM, ScD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 

Pamela Shaw, PhD, MS; Kaiser Permanente Washington Health Research Institute, Seattle, WA

Fang Tian, MPH, MHS, PhD; Wei Liu, PhD; Jenni Li, PhD; Jose Hernandez, RPh, MPH, MSc, PhD; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Hana Lee, MS, PhD; Office of Biostatistics, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD