Augmenting Date of Death & Cause of Death Ascertainment in Sentinel

    Basic Details
    Date Posted
    Wednesday, March 16, 2022
    Status
    In progress
    Description

    Administrative healthcare claims and electronic health records (EHRs) are limited in their capture of information on the fact and cause of death, particularly when a death occurs outside of a hospitalization. This project will develop a set of open-source algorithms to augment the assessment of mortality in EHR data through probabilistic linkages to additional mortality data sources. Outpatient EHR encounter data at two healthcare systems will be augmented with additional sources of mortality data including publicly available obituary and social media data, as well as national and state death certificate registries, to enhance capture of date of death. Machine learning will then be applied to develop probabilistic estimates of cause of death. Development of these and other generalizable approaches to improve death ascertainment can improve the validity of Sentinel activities using mortality as an endpoint. The Innovation Center (IC) will collaborate with experts at Vanderbilt University Medical Center (VUMC), Mass General Brigham (MGB), and Research Triangle Institute (RTI) International.

    Information
    Data Source(s)
    Electronic health record (EHR) data, national and state death certificate registry data, online obituary and social media data containing death information
    Workgroup Leader(s)

    Michael E. Matheny, MD, MS, MPH; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN

    Judith C. Maro, PhD, MS; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

    Rishi Desai, PhD; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Workgroup Member(s)

    Ruth Reeves, PhD; Mirza Khan, MD; Dax Westerman, MS; Joshua Osmanski, MS; Amy Perkins, MS; Daniel Park; Vanderbilt University Medical Center, Nashville, TN

    Josh Lin, MD, MPH, ScD; Shirley Wang, PhD, ScM; Luke Zabotka; Brigham and Women’s Hospital, Boston, MA

    Melissa McPheeters, PhD, MPH; RTI International, Durham, NC

    Aida Kuzucan, PhD, PharmD; Xi Wang, PhD, MPH; Catherine Corey, MSPH; Jose Hernandez PhD, MSc, MPH, RPh; US Food and Drug Administration, Silver Spring, MD

    Candace Fuller, PhD; Kevin Coughlin, MA; Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA