Skip to main content

Characteristics of Patients Using Anti-Diabetic Agents in the Patient-Centered Clinical Research Network (PCORnet): An Exploratory Query of a Network of Electronic Health Records

    Basic Details
    Date Posted
    Status
    Complete
    Medical Product
    anti-diabetic agent (ADA)
    sitagliptin
    sodium-glucose cotransporter-2 (SGLT-2) inhibitor
    Description

    The objective of this request was to assess the feasibility of using national Patient-Centered Clinical Research Network (PCORnet) data to complement results from queries run against the Sentinel Distributed Database (SDD). PCORnet is comprised of electronic health record data. This request aims to describe the demographic, vital, and clinical characteristics of patients receiving a prescription for sodium-glucose cotransporter-2 (SGLT-2) inhibitors and other select anti-diabetic medications.

    We used a retrospective study design to identify prevalent users of SGLT-2 inhibitors or sitagliptin within the PCORnet network between March 1, 2013, and June 30, 2018. We included data from 25 PCORnet Data Marts in this report. We distributed this request on October 2, 2019.

    Information
    Time Period
    https://www.sentinelinitiative.org/sites/default/files/Drugs/Assessments/Final_Report_fda_pmp_wp001.pdf
    Population / Cohort
    All individuals
    Data Source(s)
    Patient-Centered Clinical Research Network (PCORnet)
    Workgroup Leader(s)

    Michael Nguyen, MD; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD

    Jessica Sturtevant, ScM; PCORnet Coordinating Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

    Workgroup Member(s)

    Christian Hampp, PhD; David Graham, MD, MPH; Yandong Qiang, MD, PhD, MPH; Center for Drug Evaluation and Research, FDA, Silver Spring, MD

    Casie Horgan, MPH; Soowoo Back, MPH; Lindsey Petro; PCORnet Coordinating Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

    Tiffany Siu Woodworth, MPH, MBA; Susan Forrow; Judith C. Maro, PhD; Richard Platt, MD, MSc; Sentinel Operations Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA