The purpose of this activity was to develop a White Paper that addresses the suitability of using Sentinel to estimate vaccine effectiveness. The three aims were:
- Provide an overview of study designs and methods used to estimate vaccine effectiveness in claims and electronic health data.
- Address the strengths and limitations of using Sentinel data and infrastructure to estimate vaccine effectiveness.
- If estimating vaccine effectiveness in Sentinel is feasible, the most suitable study design will be selected to implement Sentinel and potential use cases will be provided.
Meghan Baker, MD, ScD; Catherine Panozzo, MPH, PhD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA
Maria Said, MD, MHS; Azadeh Shoaibi, MS, MHS; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
Roger Baxter; Bruce Fireman, MD; Nicola Klein, MD, PhD; Kaiser Permanente Northern California, Vaccine Study Center, Oakland, CA
Elizabeth Dee, MPH; Sandra Feibelmann, MPH; Hana Lipowicz, MPH; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA
Kevin Fahey; America’s Health Insurance Plans, Inc., Washington, DC, Department of Population Medicine
Lisa Jackson, MD, MPH; Kaiser Washington Health Research Institute, Seattle, WA
James D. Nordin, MD, MPH; HealthPartners Institute for Education and Research, Minneapolis, MN
Deepa Arya, MD, MPH, MBA; Richard A. Forshee, PhD; Hector S. Izurieta, MD, MPH; Yun Lu, PhD; David Menschik, MD, MPH; Douglas Pratt, MD, MPH; Jane Woo, MD; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
Carla V. Rodriguez, PhD, MPH; Mid-Atlantic Kaiser Permanente Research Institute, Rockville, MD
Nandini Selvam, PhD, MPH, HealthCore Inc, Alexandria, VA