The Innovation Center (IC) will build a development network of commercial Data Partners – Mass General Brigham, Kaiser Permanente Washington Health Research Institute, Duke Clinical Research Institute, and Vanderbilt University Medical Center – to enable ready access to linked Electronic Health Record (EHR) - claims data, including access to unstructured and structured information. More specifically, the IC will establish procedures for linkage of EHRs with insurance claims data, convert structured data from EHRs and linked claims from the Data Partner sites into a Sentinel Common Data Model (SCDM), develop a standardized process for storage of free text notes locally at each site and develop steps for routine meta-data extraction, and identify one or more use cases in collaboration with the U.S Food and Drug Administration (FDA) to leverage free text notes data from the development network sites. By the end of the performance period, Sentinel investigators will have unrestricted access to granular data from the development network to continue critical methods development work, including data science innovations and machine learning, to advance scalable solutions to address Active Risk Identification and Analysis (ARIA) System insufficiencies.
Rishi J. Desai, PhD; Division of Pharmacoepidemiology and Pharmacoeconomics, Mass General Brigham, Boston, MA; Anjum Khurshid, MD, PhD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA
Patricia Bright, PhD; Jose J. Hernandez, RPh, MPH, MSc, PhD; Silvia Perez-Vilar, PhD, PharmD; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
Keith Marsolo, PhD; Department of Population Health Sciences, Duke University School of Medicine, Durham, NC
David Carrell, PhD; Kaiser Permanente Washington Health Research Institute, Seattle, WA
Michael E. Matheny, MD, MS, MPH; Josh C. Smith, PhD; Ruth Reeves, PhD; Katherine Simon; Daniel Park; Taylor Thurston, DHSc; Daniel Fabbri, PhD; Robert Winter; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN
Daniel Scarnecchia, MPIA; Dan Kiernan; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA