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Effects of Medical Products on Suicidal Ideation and Behavior

Basic Details
Date Posted
Status
Complete
Health Outcome(s)
severe mental illness
suicidal behavior
suicidal ideation
Description

The project team, comprised of members from Kaiser Permanente Washington Health Research Institute (KPWHRI), Kaiser Permanente Northern California, Division of Research (KPNC), Kaiser Permanente Southern California (KPSC), Henry Ford Health System (HFHS), and Harvard Pilgrim Health Care Institute (HPHC), proposes a comprehensive program of infrastructure development, methods development, and innovative research to generate real-world evidence of suicide and suicidal ideation in the United States.  The goal of this project is to enable a robust future program of research to evaluate the effects of medical products on suicidal ideation and behavior. Specific aims include:

  1. Augmenting data partners’ infrastructure (i.e. Health Care Systems Research Network (HCSRN), Center for Effectiveness and Safety Research (CESR), Mental Health Research Network (MHRN), Sentinel Common Data Model (SCDM)) to support study of severe mental illness, suicidal ideation, and suicidal behavior using patient reported outcome (PRO) data. 
  2. Evaluate and improve generalizability of models predicting suicidal behavior.
Deliverable(s) (1)
Toolkit for Assessing and Mitigating Risk of Re-identification when Sharing Data Derived from Health Records
Information
Population / Cohort
Individuals with patient reported outcome data available, linked with Sentinel Distributed Database core enrollment and medical & pharmacy utilization tables
Data Source(s)
Sentinel Distributed Database (SDD)
Workgroup Leader(s)

Gregory E. Simon, Robert Penfold; Kaiser Permanente Washington Health Research Institute, Seattle, WA

Richard Platt; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Workgroup Member(s)

Nicolas Beaulieu, Jeff Brown, Darren Toh, Malcom Rucker, April Duddy, Suzanne Carter, Julie Richard, John Connolly, Xiaojuan Li, Di Shu, Alicia Muzzi, Bridget Nolan; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Belinda Operskalski, Brian Ahmedani, Chris Stewart, Denise Boudreau, Erika Holden, Maricela Cruz, Rob Wellman, Rod Walker, Susan Shortreed, Tara Grace, Yates Coley, Yonah Karp; Kaiser Permanente Washington Health Research Institute, Seattle, WA

Andrea Hessel Kline-Simon, Christina Grijalva, Estibaliz M. Iturralde, Stacy Sterling, Sujaya Parthasarathy; Kaiser Permanente Northern California, Oakland, CA

Jean Lawrence, Karen Coleman, Lee J. Barton; Kaiser Permanente Southern California, Downey, CA

Brian Ahmedani, Tae Yoon, Yong Hu, Joslyn Westphal; Henry Ford Health System, Detroit, MI

Michael Nguyen, Brian Kit, Andrew Mosholder, Dinci Pennap, Jamila Mwidau, Jean Kim, Marc Stone, Michael Davis, Michelle Horner, Richard Scott Swain, Sai Dharmarajan, Yong Ma, Zimri Yaseen; US Food and Drug Administration, Silver Spring, MD