Details
The goal of this project will be to evaluate the sensitivity of results from 1:1 matched analyses related to comparator group sampling. As 1:1 propensity score matching is commonly used in Sentinel Level 2 analyses, it is critical to understand for future assessments using this tool whether the model-based confidence intervals obtained from the Propensity Score tool need to account for additional sources of variability. This project will adopt a plasmode-based simulation framework to examine the impact of accounting for additional sources of uncertainty in PS-matched analyses.
Additional Information
Contributors
Rishi J. Desai, PhD, MS; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Younathan Abdia, PhD; Jessica Franklin, PhD; Joshua J. Gagne, PharmD, ScD; Richard Wyss, PhD; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
Margaret Johnson; Darren Toh, ScD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA
Sara Karami, PhD, MPH; Center for Drug Evaluation and Research, FDA, Silver Spring, MD
Hana Lee, PhD; Office of Biostatistics, Center for Drug Evaluation and Research, FDA, Silver Spring, MD
Michael Nguyen, MD; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD