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Outcome-Based TreeScan Analyses (DrugSCAN)

Basic Details
Date Posted
Status
Complete
Health Outcome(s)
Achilles tendon rupture (ATR)
angioedema
Description

This activity will investigate the feasibility of conducting outcome-based TreeScan analyses within the Mini-Sentinel Distributed Database (MSDD) using angioedema and Achilles tendon rupture (ATR) as test examples. This activity will assess whether TreeScan is able detect known associations at the specific drug and class level.

Deliverable(s) (1)
Monitoring All Drugs for a Specific Outcome in the Sentinel System
Information
Data Source(s)
Mini-Sentinel Distributed Database (MSDD)
Related Links
Related Link(s)
TreeScan (Software for the Tree-Based Scan Statistic)
Workgroup Leader(s)

Judith C. Maro, PhD; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Workgroup Member(s)

Martin Kulldorff, PhD; Department of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA

Jeff Brown, PhD; Inna Dashevsky, MS; Carolyn Balsbaugh, MP; David Cole, BM; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA

Gerald Dal Pan, MD, MHS; Center for Drug Evaluation and Research, FDA, Silver Spring, MD