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Patient Characteristics, Pain Treatment Patterns, and Incidence of Total Joint Replacement in a US Population With Osteoarthritis

    Basic Details
    Reagan-Udall Foundation

    Currently available medications for chronic osteoarthritis pain are only moderately effective, and their use is limited in many patients because of serious adverse effects and contraindications. The primary surgical option for osteoarthritis is total joint replacement (TJR). The objectives of this retrospective, multicenter, cohort study were to describe the treatment history of patients with osteoarthritis receiving prescription pain medications and/or intra-articular corticosteroid injections, and to estimate the incidence of TJR in these patients. Health plan administrative claims data (January 1, 2013, through December 31, 2019) of adult patients with osteoarthritis in the Innovation in Medical Evidence Development and Surveillance Distributed Database, a subset of the US FDA Sentinel Distributed Database, were utilized. Patients were analyzed in two cohorts: those with prevalent use of "any pain medication" (prescription non-steroidal anti-inflammatory drugs [NSAIDs], opioids, and/or intra-articular corticosteroid injections) using only the first qualifying dispensing (index date); and those with prevalent use of "each specific pain medication class" with all qualifying treatment episodes identified.



    Mayura Shinde, Carla Rodriguez-Watson, Tancy C Zhang, David S Carrell, Aaron B Mendelsohn, Young Hee Nam, Amanda Carruth, Kenneth R Petronis, Cheryl N McMahill-Walraven, Aziza Jamal-Allial, Vinit Nair, Pamala A Pawloski, Anne Hickman, Mark T Brown, Jennie Francis, Ken Hornbuckle, Jeffrey S Brown, Jingping Mo