Understanding how real-world outcome variables are developed informs their applicability to a variety of use-cases in oncology care and research. We need to ensure these outcome variables are of high-quality in order to have high confidence in the conclusions drawn from analyses of the resulting endpoints. Flatiron developed a composite mortality variable because a complete, timely single source of real-world death data does not exist. Our mortality variable is a combination of structured data from the EHR, unstructured documents (such as end of treatment notes or condolence letters), Social Security Death Index (SSDI) data, and obituary data.
Rebecca Miksad, MD, MPH