Skip to main content

Assessing the Impact of the New ICD‐10‐CM Coding System on Pharmacoepidemiologic Studies — An Application to the Known Association Between Angiotensin‐Converting Enzyme Inhibitors and Angioedema

    Basic Details

    The purpose of this manuscript is to replicate the well‐established association between angiotensin‐converting enzyme inhibitors versus beta blockers and angioedema in the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD‐10‐CM) era. The authors conducted a retrospective, inception cohort study in a large insurance database formatted to the Sentinel Common Data Model. The authors concluded that the adjusted hazard ratios across different diagnostic coding eras and the use of simple-forward mapping versus simple-backward mapping and forward-backward mapping produced numerically different but clinically similar results. Additional investigations as ICD‐10‐CM data accumulate are warranted.


    Catherine A. Panozzo, Emily C. Welch, Tiffany S. Woodworth, Ting‐Ying Huang, Qoua L. Her, Joshua J. Gagne, Jenny W. Sun, Catherine Rogers, Talia J. Menzin, Max Ehrmann, Katherine E. Freitas, Nicole R. Haug, Sengwee Toh

    Corresponding Author

    Catherine A. Panozzo, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401, Boston, MA 02215 USA. Email address: