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Evaluation of Propensity Scores, Disease Risk Scores, and Regression in Confounder Adjustment for the Safety of Emerging Treatment with Group Sequential Monitoring

    Basic Details

    The objective of this study was to evaluate regression, matching, and stratification on propensity score (PS) or disease risk score (DRS) in a setting of sequential analyses where statistical hypotheses are tested multiple times.


    Stanley Xu PhD, Susan Shetterly MS, Andrea J. Cook PhD, Marsha A. Raebel PharmD, Sunali Goonesekera MS, Azadeh Shoaibi PhD, MS, MHS, Jason Roy PhD, Bruce Fireman MA

    Corresponding Author

    S. Xu, Institute for Health Research, Kaiser Permanente Colorado, PO Box 378066, Denver, CO 80237, USA. Email: