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Identification and Validation of Anaphylaxis Using Electronic Health Data in a Population-Based Setting

    Basic Details

    Anaphylaxis is a life-threatening allergic reaction that is difficult to identify accurately with administrative data. We conducted a population-based validation study to assess the accuracy of International Classification of Diseases, Tenth Revision (ICD-10) diagnosis codes for anaphylaxis in outpatient, emergency department, and inpatient settings.

    In an integrated healthcare system in Washington State, we obtained medical records from healthcare encounters with anaphylaxis diagnosis codes (potential events) from October 2015 to December 2018. To capture events missed by anaphylaxis diagnosis codes, we also obtained records on a sample of serious allergic and drug reactions. Two physicians determined whether potential events met established clinical criteria for anaphylaxis (validated events).


    Maralyssa A. Bann, David S. Carrell, Susan Gruber, Mayura Shinde, Robert Ball, Jennifer C. Nelson, James S. Floyd

    Corresponding Author

    James S. Floyd, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA