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A Protocol for Active Surveillance of Acute Myocardial Infarction in Association with the use of a New Antidiabetic Pharmaceutical Agent

    Basic Details
    Medical Product
    oral antidiabetic medication
    Health Outcome(s)
    acute myocardial infarction (AMI)

    This article describes a protocol for active surveillance of acute myocardial infarction (AMI) in users of a recently approved oral antidiabetic medication, saxagliptin, along with several comparators, and provides the rationale for decisions made in drafting the protocol.


    Bruce Fireman MA; Sengwee Toh ScD; Melissa G. Butler PharmD, PhD, MPH; Alan S. Go MD; Hylton V. Joffe MD, MMSc; David J. Graham MD, MPH; Jennifer C. Nelson PhD; Gregory W. Daniel PhD, MPH, RPH; Joe V. Selby MD, MPH

    Corresponding Author

    Bruce Fireman, Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. E-mail: