Testing Routine Querying Tools with Known Positive Exposure-Outcome Associations: Angioedema Events After Use of Angiotensin-Converting Enzyme (ACE) Inhibitors Versus Beta-blockers

Patrick Archdeacon, MD; Office of Medical Policy, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Ryan Carnahan, PharmD, MS, BCPP; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA

Elizabeth Chrischilles, MS, PhD; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA

April Duddy, MS; Candace Fuller, PhD; Hannah Katcoff, MPH; Jennifer R. Popovic, DVM, MA; Darren Toh, ScD; Tiffany S. Woodworth, MPH; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 

Joshua Gagne, PharmD, ScD; Sebastian Schneeweiss, MD, ScD; Shirley V. Wang, PhD; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA

Xu Han, PharmD, PhD, MS; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Sean Hennessy, PharmD, PhD; Charles E. Leonard, PharmD, MSCE; Center for Clinical Epidemiology and Biostatistics and Center for Pharmacoepidemiology Research and Training, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Jie Li, PhD, MBBS; Marsha Reichman, PhD; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD

Tamra E. Meyer, PhD; Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD