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Concomitant Use of Opioid Analgesics and Cytochrome P450 (CYP) Inhibitors and Inducers

    Basic Details
    Date Posted
    Thursday, February 1, 2018
    Medical Product
    CYP inducer
    CYP inhibitor

    The goal of this query was to estimate the proportion of incident oxycodone and oxymorphone users concomitantly using a selection of cytochrome P450 (CYP) enzyme inhibitors and inducers in the Sentinel Distributed Database (SDD). Data from January 1, 2013 to December 31, 2016 from 16 health plans contributing to the SDD were included in this report. This request was distributed on June 2, 2017.

    Additional Details
    FDA Center
    Time Period
    January 1, 2013 - December 31, 2016
    Study Type
    Modular Program
    Assessment Type
    Safety Analyses
    Population / Cohort
    All individuals
    Data Sources
    Sentinel Distributed Database (SDD)