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Thromboembolic Stroke, Major Extracranial Bleeding, Gastrointestinal Bleeding, and Intracranial Hemorrhage following Direct Oral Anticoagulant Use in Patients Aged 65 or Older: An Inverse Probability of Treatment Weighting (IPTW) Analysis

    Basic Details
    Date Posted
    Medical Product
    Health Outcome(s)
    gastrointestinal bleeding
    intracranial hemorrhage
    major extracranial bleeding
    thromboembolic stroke

    This analysis investigates the comparative risk of thromboembolic stroke, intracranial hemorrhage, gastrointestinal bleeding, and major extracranial bleeding outcomes among dabigatran, rivaroxaban, and apixaban users aged over 65 years with non-valvular atrial fibrillation in the Sentinel Distributed Database (SDD). This analysis used inverse probability of treatment weighting (IPTW) to adjust for potential confounding, in contrast to a previous request which used propensity score matching.

    The study period included data from October 19, 2010 through September 30, 2015.

    The analytic package associated with this analysis can be found externally in Sentinel's Git Repository located here. The Git Repository serves as Sentinel's version control tracking system for analytic packages and technical documentation.