Algorithms to Estimate Start of Pregnancy Using In-Vitro Fertilization (IVF), Intrauterine Insemination (IUI), and Select Prenatal Tests among Pregnancies Resulting in a Live-Born Delivery

    Basic Details
    Date Posted
    Thursday, August 27, 2020
    Status
    Complete
    Description

    In this analysis we estimated start of pregnancy using in-vitro fertilization (IVF), intrauterine insemination (IUI), and select prenatal tests among pregnancies resulting in a live-born delivery in the Sentinel Distributed Database (SDD). This request includes two reports:

    • Report 1: We estimated in-vitro fertilization (IVF) and intrauterine insemination (IUI) procedure utilization by gestational age among pregnancies resulting in a live-born delviery. The study period included data from January 1, 2006 to December 31, 2017. We distributed the request to 16 Data Partners on May 23, 2018.
    • Report 2: We estimated utilization of prenatal tests of interest among pregnancies resulting in a live-born delivery and compared test-based algorithms for pregnancy start with the validated Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) algorithm. The study period included data from January 1, 2006 to January 31, 2018. We distributed the request to 16 Data Partners on August 15, 2018.
    Additional Details
    FDA Center
    CDER
    Time Period
    January 1, 2006 - January 31, 2018
    Study Type
    Modular Program
    Assessment Type
    Exploratory Analyses
    Population / Cohort
    Females 15 to 45 years of age
    Data Sources
    Sentinel Distributed Database (SDD)