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Testing Routine Querying Tools with Known Positive Exposure-Outcome Associations: Clostridium difficile Events After Use of Oral Clindamycin versus Penicillins

    Basic Details
    Date Posted
    Medical Product
    Health Outcome(s)
    clostridium difficile

    This statistical methods project is one of four workgroups that used exposure/outcome pairs with known positive associations to test Mini-Sentinel (now Sentinel) routine querying tools. Specifically, these known positive associations tested the Cohort Identification and Descriptive Analysis (CIDA) tool in combination with the Propensity Score Analysis (PSA) tool.

    This known positive test case assessed oral clindamycin versus penicillins and risk of clostridium difficile infection. Data from January 1, 2006 to December 31, 2013 from 10 health plans contributing to the Mini-Sentinel Distributed Database (MSDD) were included in this report. This request was distributed on April 2, 2015.