Osteoporotic Fractures Following Lupron Depot-PED Use: A Multiple Factor Matched Analysis

    Basic Details
    Date Posted
    Monday, July 1, 2019
    Status
    In progress
    Medical Product
    Lupron Depot-PED
    Health Outcome(s)
    fracture
    hip replacement
    osteoporotic fracture
    temporomandibular joint replacement
    Description

    This analysis investigates whether children with centralized precocious puberty (CPP) who are exposed to Lupron Depot-PED are at higher risk for fractures compared to children who are unexposed to Lupron Depot-PED in the Sentinel Distributed Database.

    The primary outcome assessed in this analysis is osteoporotic fractures. The secondary outcomes are any fracture, hip replacement, and temporomandibular joint replacement.

    The analytic package associated with this analysis can be found externally in Sentinel's Git Repository located here. The Git Repository serves as Sentinel's version control tracking system for analytic packages and technical documentation.