Utilization of Post-Exposure Prophylaxis to Prevent Lyme Disease in a Large US Healthcare Database

Lyme disease is the most common vector-borne disease in the United States (US) and is on the rise. Post-exposure prophylaxis (PEP) with a single dose of doxycycline can effectively prevent Lyme disease after a high-risk tick bite but patterns of PEP use have not been previously described. This poster identifies and describes single-dose doxycycline (≤200 mg) dispensings during January 2009 to December 2019 in the Food and Drug Administration Sentinel Distributed Database (SDD).