Trends in Single-Dose Doxycycline for Lyme Disease Prophylaxis in the United States: A Descriptive Analysis

Lyme disease can be prevented by taking one dose of doxycycline (200 mg or 4.4 mg/kg for persons <45 kg) when administered within 72 hours after a high-risk tick bite. To shed light on patterns of Lyme disease post-exposure prophylaxis (PEP) in the United States, we characterized the frequency and patterns of single dose doxycycline over time, and described characteristics of individuals with these dispensings in the Sentinel Distributed Database (SDD).

The study period includes data from January 1, 2009 to February 29, 2020. We distributed this request to seven Sentinel Data Partners on November 9, 2020.